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KMID : 0387420100210040151
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Korean Society of Oriental Neuropsychiatry
2010 Volume.21 No. 4 p.151 ~ p.161
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A Systematic Review of Clinical Studies for Herbal Medicine of Dementia - based on Korean Literature -
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Kwon Yong-Ju
Cho Hye-Young
Hwang Wei-Wan
Cho Seung-Hun
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Abstract
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Objectives: This study aimed to evaluate any clinical studies regarding the herbal medicine for dementia focusing on Korean literature for future rigorous clinical research.
Methods: Every article relevant to dementia was initially obtained from oriental medical related journals by electronic search at journal web sites or manual searches. Journals were limited to those registered with the Korea Research Foundation. From initial findings. two independent reviewers selected clinical articles and these articles were further analyzed separately by predefined criteria according to prospective and retrospective studies. For randomized controlled trial and non randomized controlled trial. quality assessment was also conducted.
Results: From ninety seven patients initially obtained articles. twenty three patients were finally analyzed. One article was randomized controlled study. Four articles were prospective whereas eighteen patients were retrospective. In the qualitative evaluation of prospective articles. there was deduction regarding pre-calculated study size and prospective data collecting. Assessment measurement most frequently used was Mini Mental State Examination. The order of frequency of use herbs were identified.
Conclusions: According to our study. the herbal medicine for dementia in general showed a positive effect in the cognitive aspects of dementia patients. Further well-designed randomized controlled studies should be conducted.
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KEYWORD
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Systematic Review, Dementia, Herbal medicine, Clinical trial
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